| In 1997 it has been demonstrated that the enzyme
tissue transglutaminase, being released from cells
during inflammation, is the major if not sole target for
endomysial antibodies in celiac disease.
Celiac disease is a chronic disease affecting children as
well as adults, with a genetic predisposition. The disease
is elicited through the uptake of food containing
gluten. The toxic agent is gliadin, the alcohol soluble
fraction of gluten. It’s uptake leads to mucosal lesion
of the small-intestine, due to a loss of absorptive villi
leading to malabsorption of nutrients. As a result, the
patient can show symptoms, like: Diarrhoea, slow
growth, vomiting, tiredness or bad appetite.
The risk of an intestinal lymphoma or any other
gastrointestinal neoplasm is increased, if the disease
remains untreated. Furthermore, longstanding untreated
coeliac disease, even if clinically silent, predisposes
for other autoimmune diseases. |
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 |
 |
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| Tests |
12 x 8 Tests |
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| Calculation |
quantitative |
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|
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| Range |
0 – 200 U/ml |
|
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|
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| Cut-off |
10 U/ml
Screen: 15 U/ml |
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|
| Sensitivity |
1 U/ml |
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| Calibration |
arbitrary |
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| Substrate |
TMB / 450 nm |
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Instruction for Use: ORG 540A-0509-01-gb.pdf
Material-Safety-Datasheet: org 540a.pdf